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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
1980-12-18
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pubmed:abstractText |
The synthesis and biological activity of the methyl esters of (+)-12-fluoroPGF2 alpha, (+)-15-epi-12-fluoroPGF2 alpha, (-)-ent-12-flurorPGF2 alpha, and (-)-ent-15-epi-12-fluoroPGF2 alpha are described. Each fluoroprostaglandin has been evaluated from pregnancy interruption in the hamster and smooth-muscle stimulating effects on gerbil colon and hamster uterine strips. All fluoroprostaglandins synthesized were shown to be neither substrates for the 15-hydroxyprostaglandin dehydrogenase nor inhibitors of the enzyme.
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pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
23
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1072-7
|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7420351-Abortifacient Agents, Nonsteroidal,
pubmed-meshheading:7420351-Animals,
pubmed-meshheading:7420351-Cricetinae,
pubmed-meshheading:7420351-Female,
pubmed-meshheading:7420351-Gerbillinae,
pubmed-meshheading:7420351-Models, Molecular,
pubmed-meshheading:7420351-Muscle, Smooth,
pubmed-meshheading:7420351-Muscle Contraction,
pubmed-meshheading:7420351-Pregnancy,
pubmed-meshheading:7420351-Prostaglandins F, Synthetic,
pubmed-meshheading:7420351-Stereoisomerism,
pubmed-meshheading:7420351-Structure-Activity Relationship,
pubmed-meshheading:7420351-Uterine Contraction
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pubmed:year |
1980
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pubmed:articleTitle |
Fluoroprostaglandins: synthesis and biological evaluation of the methyl esters of (+)-12-fluoro-, (-)-ent-12-fluoro-, (+)-15-epi-fluoro-, and (-)-ent-15 epi-12-fluoroprostaglandin F2 alpha.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|