Linked Life Data

7418444

Source:http://linkedlifedata.com/resource/pubmed/id/7418444

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
105
pubmed:dateCreated
1980-12-16
pubmed:abstractText
The growth promoting activity of a synthesis tripeptide, glycyl-L-histidyl-L-lysine (GHL) as a possible serum substitute was determined using human KB cells. GHL was found to stimulate the growth of human KB, and HeLa cells, but not WI-38 cells when employed in serum limited medium containing bovine serum albumin (BSA). The rate of growth of cells in this medium was similar to that of cells grown in medium containing 5% serum. While BSA did enhance slightly the growth of cells, its major function appeared to be in maintaining cellular viability. The growth promoting activity was specific for GHL; other synthetic peptides which were similar in composition had no activity, but they did interfere with the growth promoting activity of GHL. These observations suggest that by modifying GHL, analogues could be developed which might regulate cell growth and be useful in cancer chemotherapy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0011-4529
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-25
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Glycyl-L-histidyl-L-lysine, a growth promoting factor for human cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't