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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1980-11-20
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pubmed:abstractText |
1. When 3-phenoxy[14C]benzoic acid was dosed orally (0.76 mg/kg) to rats, 1--3% of the administered radioactivity was found in the skin four days after dosing. Approximately 90% of this residue was unchanged 3-phenoxybenzoate, 10% was a neutral compound. 2. The residue in the skins of rats dosed with 193 mg of 3-phenoxybenzoic acid over 7 days (c. 100 mg/kg per day) contained 40% 3-phenoxybenzoate and 60% neutral metabolites. 3. The components were separated and purified by gel permeation, absorption and t.l.c. and analysed by mass spectrometry. 4. 2- and 3-(3-Phenoxybenzoyl)dipalmitins were major components of the neutral metabolite.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0049-8254
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
349-54
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7415217-Animals,
pubmed-meshheading:7415217-Biotransformation,
pubmed-meshheading:7415217-Dose-Response Relationship, Drug,
pubmed-meshheading:7415217-Female,
pubmed-meshheading:7415217-Hydrogen-Ion Concentration,
pubmed-meshheading:7415217-Male,
pubmed-meshheading:7415217-Pharmaceutical Preparations,
pubmed-meshheading:7415217-Rats,
pubmed-meshheading:7415217-Skin,
pubmed-meshheading:7415217-Triglycerides
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pubmed:year |
1980
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pubmed:articleTitle |
Xenobiotic triglyceride formation.
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pubmed:publicationType |
Journal Article
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