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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1980-11-20
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pubmed:abstractText |
The p-hydroxylation of aniline has been traditionally determined by measurement of p-aminophenol (PAP) formation. Comparison of isotopic and colorimetric procedures indicate that the actual amount of aniline metabolized exceeds the among of PAP recovered. Data suggest that enhancement of p-hydroxylation of aniline by acetone, malaoxon and paraoxon may result from inhibition of further metabolism of PAP by the microsomal cytochrome b5-dependent desaturase system. Involvement of the desaturase system is supported by observations that: (a) metabolism of PAP was reduced by starvation and stimulated when starvation was followed by feeding a high carbohydrate diet; (b) enrichment of hepatic microsomes with detergent purified cytochrome b5 decreased the amount of aniline apparently metabolized, as measured by the amount of PAP recovered, and (c) a high correlation occurred between effects of acetone, malaoxon and paraoxon on reoxidation of cytochrome b5 and capacity of these three compounds to enchance aniline metabolism.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0031-7012
|
pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
153-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7413717-Aminophenols,
pubmed-meshheading:7413717-Aniline Compounds,
pubmed-meshheading:7413717-Animals,
pubmed-meshheading:7413717-Cytochromes,
pubmed-meshheading:7413717-Diet,
pubmed-meshheading:7413717-Hydroxylation,
pubmed-meshheading:7413717-Kinetics,
pubmed-meshheading:7413717-Male,
pubmed-meshheading:7413717-Microsomes, Liver,
pubmed-meshheading:7413717-Oxidation-Reduction,
pubmed-meshheading:7413717-Rats
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pubmed:year |
1980
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pubmed:articleTitle |
Inhibition of p-aminophenol metabolism: a possible mechanism of enhancement of aniline hydroxylation.
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pubmed:publicationType |
Journal Article,
In Vitro
|