Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-11-24
pubmed:abstractText
The requirement of cholesterol for myoblast fusion has been linked to the primary step in the fusion process, calcium-dependent aggregation (recognition). Inhibition of cholesterol synthesis with 25-hydroxycholesterol or compactin in the absence of exogenous lipid dramatically inhibits calcium-mediated aggregation and concomitant fusion within several hours. Restimulating cholesterol synthesis or supplying exogenous cholesterol rapidly restores aggregation activity. Over this time period, however, the sterol:phospholipid ratio is unaltered, suggesting a local rather than a general membrane cholesterol requirement for the expression of aggregation activity. The aggregation response to a change in sterol availability occurs on a shorter time scale than that required to inhibit the synthesis of the protein(s) with aggregation activity; thus, the cholesterol-requiring step is posttranslational. We suggest that the assembly or maintenance of the aggregation activity depends on a continued local supply of cholesterol.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-100355, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-13252080, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-13641241, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-14228472, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-164478, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-176160, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-4278181, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-4361682, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-4372284, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-5104198, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-565779, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-5947043, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-6157695, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-624722, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-844098, http://linkedlifedata.com/resource/pubmed/commentcorrection/7410480-885292
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
820-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Cholesterol availability modulates myoblast fusion.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.