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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1980-11-20
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pubmed:abstractText |
Lungs accumulate 5-hydroxytryptamine (serotonin, 5-HT) from the perfusate by a sodium-dependent, energy-requiring, saturable process. The rate-limiting step for uptake is the transport of 5-HT and not its subsequent metabolism to 5-hydroxyindoleacetic acid. Autoradiographic studies indicate that the pulmonary endothelium is the cellular site of uptake. The effect of hyperoxia on lung clearance of 5-HT was studied with isolated perfused and ventilated lungs from rats that were previously exposed to hyperoxia. Lungs were perfused with recirculating electrolyte solution and initial [5-HT] of 0.24 microM. The calculated fractional 5-HT clearance (fracion of 5-HT removed in a single pass) ws 0.77 +/- 0.02 (mean +/- SE: n = 44) for control rats. Mean fractional clearance decreased by 20% in rats exposed to 1 atm O2 for 18 hr and 30% after 4 atmospheres absolute (ata) O2 for 1 hr (p < 0.05). The effects of O2 at 4 ata were in part reversed by exposure to air for 3.5 hr and in part prevented by injection of superoxide dismutase (60 nmole/kg body weight). This degree of O2 exposure at either 1 or 4 ata had no effect on lung content of adenine nucleotides or the distribution of 3H-5HT on autoradiography. Rats maintained for 6 weeks on a vitamin E-deficient diet showed an increased effect of hyperoxia on 5-HT clearance and did not show reversal of changes after 24 hr of air breathing. The results indicate that exposure to elevatd po2 results in reversible depression of pulmonary 5-HT clearance that is potentiated by vitamin E deficiency. This suggests alteration of pulmonary endothelial membrane transport properties due to O2 toxicity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-1130533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-1159631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-438010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-4413241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-4416998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-5044755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-5056216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-5080029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-5083550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-5089966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-5476243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-5859733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-6034481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-632178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-670032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-732350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-734241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-833074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-869322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-893279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7408797-900632
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0091-6765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7408797-Amines,
pubmed-meshheading:7408797-Animals,
pubmed-meshheading:7408797-Atmosphere Exposure Chambers,
pubmed-meshheading:7408797-Biological Transport, Active,
pubmed-meshheading:7408797-Hyperbaric Oxygenation,
pubmed-meshheading:7408797-Imipramine,
pubmed-meshheading:7408797-Lung,
pubmed-meshheading:7408797-Norepinephrine,
pubmed-meshheading:7408797-Oxygen,
pubmed-meshheading:7408797-Perfusion,
pubmed-meshheading:7408797-Rats,
pubmed-meshheading:7408797-Serotonin,
pubmed-meshheading:7408797-Vitamin E Deficiency
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pubmed:year |
1980
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pubmed:articleTitle |
Environmental influences on uptake of serotonin and other amines.
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pubmed:publicationType |
Journal Article
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