Linked Life Data

7405570

Source:http://linkedlifedata.com/resource/pubmed/id/7405570

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1980-10-21
pubmed:abstractText
Enzymatic tracer techniques to study normal and pathologic strial capillary transport pose various problems. The use of electron opaque tracers can circumvent many of these problems. Iron dextran (mol. diam 20--70 A) and ferritin (mol. diam 110 A) were injected intravenously and the mice sacrificed at intervals of 1/2, 1, 2, 5, and 24 h. The iron dextran results were unusual in that from 1/2 to 5 h after administration the tracer was present within the cytoplasmic matrix of endothelia, but by 24 h it had been cleared out. No transendothelial exchange was noted. The ferritin results were in conflict and previous results using horse-radish peroxidase. Transport of ferritin was minimal regardless of time sacrificed. No more than a few molecules were scattered about the capillary basal limina. Those molecules transported across capillaries were apparently delivered by means of the micropinocytotic system. The results suggest a blood-strial barrier similar to the blood-thymic and blood-myenteric barriers. Experimental as well as control animals exhibited strial light cells which contained ferritin-like particles within their cytoplasmic matrices. These light cells are probably reticuloendothelial type cells. Ferritin may be useful to gauge strial capillary transport alterations associated with auditory pathologies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6489
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
An evaluation of normal strial capillary transport using the electron-opaque tracers ferritin and iron dextran.
pubmed:publicationType
Journal Article