Linked Life Data

7402293

Source:http://linkedlifedata.com/resource/pubmed/id/7402293

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5765
pubmed:dateCreated
1980-10-27
pubmed:abstractText
Cell-surface proteins are believed to have important roles in cell-cell interactions during brain development, particularly in such processes as cellular adhesion, neurite outgrowth and synapse formation. The chick neural cell adhesion molecule, CAM, is a cell-surface protein specific to the nervous system and has been implicated in cell adhesion among cells and neurites of the developing retina and brain. Previous studies have shown that F(ab') fragments of antibodies directed against CAM inhibit the in vitro aggregation of cells obtained from 9-day embryonic chick retina. The specific antibody fragments also reduce the diameter of neurite fascicles that grow out from cultured dorsal root ganglia, apparently by blocking side-to-side adhesion between the neurites. In addition, anti-CAM antibodies alter the appearance of histotypic patterns in retinal cell aggregates maintained in culture for several days. We now demonstrate that the antibodies can disrupt histogenesis of the developing retina in organ culture, strengthening the notion that the cell-cell adhesion properties mediated by CAM are involved in the normal development of histological layers in the chick retina.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
488-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Antibodies to a neural cell adhesion molecule disrupt histogenesis in cultured chick retinae.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.