Linked Life Data

7401106

Source:http://linkedlifedata.com/resource/pubmed/id/7401106

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1980-10-24
pubmed:abstractText
Application of heat to aqueous solutions of nucleoside dialdehydes (periodate-oxidized nucleosides) affords the corresponding alpha,beta-unsaturated aldehydes. The reaction was first discovered during studies with adenosine deaminase and was initially investigated enzymatically until the nature of the chemical transformation was determined. A UV peak at 230-250 n, characteristic of the alpha,beta-unsaturated aldehyde group, was obtained by difference spectroscopy and affords a more practical means to study the reaction. Adenosine dialdehyde, obtained by periodate oxidation of adenosine, afforded the same product upon heating as obtained by periodate oxidation of 9-(5-deoxy-beta-D-erythro-ent-4-enofuranosyl)adenine. Further proof of identity was obtained by reduction of these compounds with sodium borohydride and comparison of the dialchols obtained to each other and to a known unsaturated dialcohol. Heating of nucleoside dialdehydes at any time is not recommended. The exact composition of nucleoside dialdehydes used in previous and current biological studies is open to question.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
795-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Heat-induced formation of alpha,beta-unsaturated nucleoside dialdehydes and their activity with adenosine deaminase.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.