Linked Life Data

7400679

Source:http://linkedlifedata.com/resource/pubmed/id/7400679

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1980-10-24
pubmed:abstractText
Immediate electrocochleographic changes have been studied in a series of patients following intravenous infusion of either tobramycin or gentamicin. In patients receiving tobramycin, as soon as peak serum levels of antibiotic were reached, a dramatic decrease occurred in the magnitude of the compound VIII nerve action potential (AP), and of the cochlear microphonic (CM). The shape of the AP also changed. The N1 component of the waveform became very small, and N2 increased in size; this is the dissociated pattern of basal coil cochlear damage. The speed of onset of these electrical changes and their apparent reversibility suggests a temporary metabolic block caused by tobramycin. No such changes were observed following infusion of gentamicin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2151
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
521-31
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Immediate effects of intravenous tobramycin and gentamicin on human cochlear function.
pubmed:publicationType
Journal Article, Case Reports