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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
3
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pubmed:dateCreated |
1980-10-24
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pubmed:abstractText |
The response to type 3 pneumococcal polysaccharide vaccination, the protective effect of type 3 pneumococcal polysaccharide vaccination, and the ability of hemagglutinating antibody to type 3 pneumococcal polysaccharide to cross the blood-brain barrier were studied in rats. Hemagglutinating antibody response to vaccination with type 3 pneumococcal polysaccharide was found to be dependent on the dose and route of inoculation. Intraperitoneal vaccination with type 3 pneumococcal polysaccharide protected the rats from subsequent intraperitoneal challenge with type 3 Streptococcus pneumoniae but had no effect after intracisternal challenge with type 3 S. pneumoniae. In the presence or absence of sterile meningeal inflammation, hemagglutinating antibody could not be found in cerebrospinal fluid of animals vaccinated intraperitoneally with type 3 pneumococcal polysaccharide. These results suggest that type 3 pneumococcal polysaccharide is antigenic in rats and intraperitoneal vaccination with type 3 pneumococcal polysaccharide does not protect against experimental meningitis because antibodies do not cross the blood-brain barrier.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-9567
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
832-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7399697-Agglutinins,
pubmed-meshheading:7399697-Animals,
pubmed-meshheading:7399697-Antibodies, Bacterial,
pubmed-meshheading:7399697-Blood-Brain Barrier,
pubmed-meshheading:7399697-Hemagglutinins,
pubmed-meshheading:7399697-Male,
pubmed-meshheading:7399697-Pneumococcal Infections,
pubmed-meshheading:7399697-Polysaccharides, Bacterial,
pubmed-meshheading:7399697-Rats,
pubmed-meshheading:7399697-Streptococcus pneumoniae,
pubmed-meshheading:7399697-Vaccination
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pubmed:year |
1980
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pubmed:articleTitle |
Antigenicity and protective effects of type 3 pneumococcal polysaccharide in rats.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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