Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-9-26
pubmed:abstractText
1. The human thymus-brain antigen, which corresponds to the murine (mouse or rat) Thy-1 antigen complex, was isolated from brain after solubilization in deoxycholate by gel-permeation chromatography, wheat-germ-lectin affinity chromatography and ion-exchange chromatography. 2. The isolated antigen is a glycoprotein displaying an apparent molecular weight of 26 000-29 000 in sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. 3. No antigen activity was found with the lipid fraction from human brain. 4. The protein has a tendency for spontaneous self-association (dimerization), leading to aggregates resistant to dissociating and reducing agents on prolonged storage. 5. The antigen is microheterogeneous with respect to size, charge (approximate isoelectric points of the monomer 7.7, 7.0 and 6.5) and to lectin-binding affinity. 6. The antigen can be reconstituted to protein-lipid vesicles. The antigen activity of solubilized antigen is strongly increased by reconstitution and that of membranes decreased by solubilization with detergent.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-1151060, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-1259153, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-14207060, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-202609, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-236308, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-278998, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-308963, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-309914, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-311810, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-356051, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-361417, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-366610, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-4130369, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-420783, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-4538915, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-4543319, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-4546942, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-4547712, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-4548649, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-4553016, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-4810936, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-4831061, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-50563, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-56177, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-56178, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-5941981, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-62283, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-62668, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-62671, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-629764, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-68924, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-68955, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-69659, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-6967725, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-79550, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-81852, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-89692, http://linkedlifedata.com/resource/pubmed/commentcorrection/7396854-938664
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
187
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-12
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Isolation and characterization of the thymus-brain antigen (analogous to thy-1 antigen) from human brain.
pubmed:publicationType
Journal Article