Linked Life Data

7395856

Source:http://linkedlifedata.com/resource/pubmed/id/7395856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-9-26
pubmed:abstractText
This report compares the history of oral contraceptive (OC) use for 715 New York state women who gave birth to malformed infants with the history for a group of 715 matched controls who gave birth to normal children. The case mothers were found to have used the OC after last menstrual period (LMP), or just before conception, slightly more often than the controls. Confidence intervals for the relative risk estimates were wide, and were significantly higher than 1.0 only among the group of women whose children had one or more major structural or anatomical malformations. Cytogenetic abnormalities and hypospadias were not associated with OC use around or after the time of conception. For women who had children with major anatomical or structural malformations, the association with OCs was stronger among the older age group. The authors found no evidence of an increased risk among women who had conveived their child after one or more pill-free menstrual cycles. Several reported studies, including this one, show a predominance of males among malformed offspring whose mothers used OCs during pregnancy. These findings indicate that the association between birth defects and OC use around the time of conception is not large, but the association is not easily reconciled with a non-causal explanation.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Congenital Abnormalities, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods--side effects, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Usage, http://linkedlifedata.com/resource/pubmed/keyword/Diseases, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/Maternal Age, http://linkedlifedata.com/resource/pubmed/keyword/Neonatal Diseases And Abnormalities, http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives--side effects, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology, http://linkedlifedata.com/resource/pubmed/keyword/Sampling Studies, http://linkedlifedata.com/resource/pubmed/keyword/Studies, http://linkedlifedata.com/resource/pubmed/keyword/Surveys
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0002-9262
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-9
pubmed:dateRevised
2006-11-15
pubmed:otherAbstract
PIP: This report compares the history of (OC) oral contraceptive use for 715 New York State women who gave birth to malformed infants with the history for a group of 715 matched controls who gave birth to normal children. The case mothers were found to have used OCs after their last menstrual period or just before conceptions slightly more often than the controls. Confidence intervals for the relative risk estimates were wide, and were significantly higher than 1.0 only among the group of women whose children had 1 or more major structural or anatomical malformations. Cytogenetic abnormalities and hypospadias were not associated with OC use around or after the time of conception. For women who had children with major anatomical or structural malformations, the association with OCs was stronger among the older age group. The authors found no evidence of an increased risk among women who had conceived their child after 1 or more pill-free menstrual cycles. Several reported studies, including this 1, show a predominance of males among malformed offspring whose mothers used OCs during pregnancy. These findings indicate that the association between birth defects and OC use around the time of conception is not large, but the association is not easily reconciled with a noncausal explanation.
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Oral contraceptives and birth defects.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.