Linked Life Data

7393969

Source:http://linkedlifedata.com/resource/pubmed/id/7393969

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1980-9-28
pubmed:abstractText
Prostaglandin (PG) D2 was studied to determine the pharmacological effects of this PG on the central nervous system. PGD2 (0.45-4.05 mg/kg) decreased spontaneous locomotor activity in rats by as much as 66% of control, however, the neuromuscular coordination of mice, treated at the same doses of PGD2, was not impaired. PGD2 (0.05-4.05 mg/kg) also increased pentobarbital sleeping time in mice from 42% to 238% of control, in a dose-related manner. PGD2 did not prevent convulsions induced in response to electroshock or pentylenetetrazol. Cats monitored for EEG responses to PGD2 infusion displayed variable sensitivity to different doses (16-3000 microgram) of drug, however, the characteristic response to PGD2 was the conversion from a uniform low voltage, fast wave pattern to high voltage, slow waves. Cats administered PGD2 were sedated and sometimes catatonic, and displayed brief periods of hypotension, bradycardia, diarrhea, analgesia and hyperthermia at higher doses of the drug. Thus, PGD2 possesses sedative properties in rodents and cats and may have a role in the central nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
747-54
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
PGD2 effects on rodent behavior and EEG patterns in cats.
pubmed:publicationType
Journal Article