Linked Life Data

7391844

Source:http://linkedlifedata.com/resource/pubmed/id/7391844

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1980-9-23
pubmed:abstractText
[131I]iodomethyl trimethylammonium chloride (I-131 TMA) was prepared by the isotope-exchange reaction of diiodomethane with Na131I, followed by reaction with trimethylamine. A specific activity of 20 microCi/mg was obtained. Tissue distributions following intravenous injection of I-131 TMA in mice showed that between 10 min and 2 hr, the highest accumulations of radioactivity were in the urine, kidney, and heart. The uptake of this compound in the heart was very rapid, and the levels of radioactivity remained fairly high up to 2 hr. At 10, 30, 60, and 120 min the heart-to-blood ratios were, respectively, 10.2, 7.7, 8.3, and 9.6. Thyroid uptake of this compound in the rats and analysis of urine samples of the mouse indicated no extensive deiodination of the compound in vivo. These results show that this compound does have potential for use in myocardial imaging. In addition, its stability in vivo makes it very useful for the radiolabeling of compounds containing quaternary ammonium moieties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0161-5505
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
679-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
In vivo stability and distribution of [131I]iodomethyl trimethylammonium chloride: concise communication.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.