Linked Life Data

7391612

Source:http://linkedlifedata.com/resource/pubmed/id/7391612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-9-26
pubmed:abstractText
Langerhans-cell-enriched epidermal cell preparations, when pulsed with antigen, can induce proliferative responses, in immune T cells, that are of the same magnitude as those induced by antigen-pulsed macrophages. Additionally, these cells bear surface receptors for Fc and C3b and display on their cell surface determinants encoded by genes of the I region of the major histocompatibility complex. Histological studies have implicated Langerhans cells in cell-mediated immune responses such as delayed contact hypersensitivity to 2,4-dinitro-1-fluorobenzene (DNFB). Langerhans cells play an important role in the induction of contact sensitivity. When murine epidermis that is naturally or artificially depleted of Langerhans cells is painted with DNFB, no sensitization occurs. More importantly, animals whose initial exposure to DNFB occurs through skin deficient in Langerhans cells are unable subsequently to mount effective hypersensitivity responses to this agent. We there believe that Langerhans cells function as peripheral antigen-presenting cells and that in their absence the host responds to antigen challenge by becoming specifically unresponsive.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Langerhans cells: sentinels of skin associated lymphoid tissue.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.