Linked Life Data

7389582

Source:http://linkedlifedata.com/resource/pubmed/id/7389582

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-9-28
pubmed:abstractText
3,3',4,4'-Tetrachloroazobenzene (TCAB) and 3,3',4',4'-tetrachloroazoxybenzene (TCAOB) are formed as contaminants during the industrial manufacturing of chloroanilide herbicides. Changes in the general body health status were evaluated in rats fed an experimental diet containing 100 ppm of TCAB or TCAOB for 120 days. A significant difference in body weight between experimental and control animals was observed. Of all major organs examined at necropsy, liver, spleen and testis weight were affected. Induction of hepatic drug-metabolizing enzymes was observed. Hematological studies indicated a definite reduction in the number of erythrocytes among TCAOB treated rats. Various parameters of serum clinical chemistry were subsequently determined. The total lipids and glutamic-oxalacetic transaminase in exposed animals were found to be elevated. Results obtained in this study coupled with our earlier findings on carcinogenicity indicate that occupational exposure to TCAB and TCAOB may cause adverse human health effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0148-0545
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
General health effects of prolonged exposure to 3,3',4,4'-tetrachloroazobenzene and 3,3',4,4'-tetrachloroazoxybenzene in rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.