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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1980-9-28
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pubmed:abstractText |
20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and the median tobramycin MIC/MBC was 6.25/25.0 micrograms/ml for all organisms studied. Median cefazolin doses of 49.0 mg/kg/day gave median peak/trough serum levels of 43.0/11.0 micrograms/ml. Median tobramycin doses of 4.3 mg/kg/day gave median peak/trough serum levels of 5.0/1.4 micrograms/ml. Checkerboard studies revealed synergy with 65% of strains. Bacteriologic and clinical success was obtained in 17 of 20 patients.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
0009-3157
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
384-96
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7389430-Acute Kidney Injury,
pubmed-meshheading:7389430-Adult,
pubmed-meshheading:7389430-Aged,
pubmed-meshheading:7389430-Anti-Bacterial Agents,
pubmed-meshheading:7389430-Bacteria,
pubmed-meshheading:7389430-Bacterial Infections,
pubmed-meshheading:7389430-Burns,
pubmed-meshheading:7389430-Cefazolin,
pubmed-meshheading:7389430-Child,
pubmed-meshheading:7389430-Child, Preschool,
pubmed-meshheading:7389430-Drug Synergism,
pubmed-meshheading:7389430-Drug Therapy, Combination,
pubmed-meshheading:7389430-Endocarditis, Bacterial,
pubmed-meshheading:7389430-Female,
pubmed-meshheading:7389430-Humans,
pubmed-meshheading:7389430-Infant,
pubmed-meshheading:7389430-Male,
pubmed-meshheading:7389430-Microbial Sensitivity Tests,
pubmed-meshheading:7389430-Middle Aged,
pubmed-meshheading:7389430-Tobramycin,
pubmed-meshheading:7389430-Wound Infection
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pubmed:year |
1980
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|
pubmed:articleTitle |
Treatment of twelve burn wound infections and eight other serious infections with cefazolin and tobramycin: in vitro and in vivo evaluation.
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pubmed:publicationType |
Journal Article
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