Linked Life Data

7381843

Source:http://linkedlifedata.com/resource/pubmed/id/7381843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1980-8-15
pubmed:abstractText
Discriminant analysis was used in the structure-activity study of antiulcerous benzoguanamines, antiinflammatory phenylacetic acids, and aminouracils. The usual discriminant analysis requires the equality of covariance matrix for the multivariate normal distribution between observation groups. When this condition is not fulfilled for some pairs of groups, a modified procedure, the "admissible" discriminant analysis after Anderson and Bahadur, was applied. In this procedure, the model of equal covariance is not the prerequisite for the analysis. As the primary criterion for selecting the best combination of variables in the discriminant functions, we used the number of misclassified compounds which is minimum. The discriminant variables were selected from the physiochemical parameters used to analyze the variation in hydrophobicity due to structural modifications. The potency scores divided into three groups for each of the three series of compounds were predicted with more than 80% accuracy, when the two-group analysis was performed for the most potent and least potent groups omitting the intermediary group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
437-44
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Structure-activity study of antiulcerous and antiinflammatory drugs by discriminant analysis.
pubmed:publicationType
Journal Article