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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1980-8-25
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pubmed:abstractText |
1. The effects on blood pressure and heart rate of prazosin and a structurally-related congener, BL-5111A, were compared in conscious and anaesthetized rats. 2. Both agents induced dose-related falls in systolic and diastolic blood pressure, with relatively little effect on heart rate. The hypotensive potency of prazosin was twenty-fold greater than that of BL-5111A. 3. The hypotensive activity of prazosin was abolished by pretreatment with the ganglionic blocking agent, pentolinium, or the alpha-adenoceptor blocking agent, phentolamine, whereas BL-5111A retained significant hypotensive activity (up to 28%) after either pretreatment. 4. Both prazosin and BL-5111A attenuated pressor responses to noradrenaline, and reversed the responses to adrenaline, prazosin being, in this respect, 6 times more potent than BL-5111A. There was a highly significant relationship between the alpha-adrenoceptor blocking activity of either agents and its hypotensive effect. 5. BL-5111A differed from prazosin in possessing, in addition to its predominant alpha-adrenoceptor blocking action, a minor component of action attributable to direct vasodilatation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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pubmed:status |
MEDLINE
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pubmed:issn |
0305-1870
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7379338-Anesthesia,
pubmed-meshheading:7379338-Angiotensin II,
pubmed-meshheading:7379338-Animals,
pubmed-meshheading:7379338-Blood Pressure,
pubmed-meshheading:7379338-Dose-Response Relationship, Drug,
pubmed-meshheading:7379338-Drug Interactions,
pubmed-meshheading:7379338-Epinephrine,
pubmed-meshheading:7379338-Heart Rate,
pubmed-meshheading:7379338-Hemodynamics,
pubmed-meshheading:7379338-Prazosin,
pubmed-meshheading:7379338-Quinazolines,
pubmed-meshheading:7379338-Rats,
pubmed-meshheading:7379338-Vasodilator Agents
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pubmed:articleTitle |
Profile of a new prazosin congener, BL-5111A. Studies in the rat.
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pubmed:publicationType |
Journal Article,
Comparative Study
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