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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1980-8-28
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pubmed:abstractText |
Hamster liver microsome-mediated [14C]aflatoxin B1 binding to DNA is inhibited by 105,000 X g liver supernatant fraction. Absolute requirement of glutathione for the inhibitory activity of the dialyzed supernatant and irreversible loss of the inhibitory activity by the heat-treated supernatant indicate involvement of glutathione S-transferase. Concomitant with inhibition of aflatoxin B1-DNA binding, the formation of an aflatoxin B1-glutathione conjugate is indicated.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0304-3835
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
143-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7379043-Aflatoxins,
pubmed-meshheading:7379043-Animals,
pubmed-meshheading:7379043-Binding Sites,
pubmed-meshheading:7379043-Cricetinae,
pubmed-meshheading:7379043-DNA,
pubmed-meshheading:7379043-Glutathione Transferase,
pubmed-meshheading:7379043-Male,
pubmed-meshheading:7379043-Mesocricetus,
pubmed-meshheading:7379043-Microsomes, Liver
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pubmed:year |
1980
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pubmed:articleTitle |
Inhibition of microsome-mediated binding of aflatoxin B1 to DNA by glutathione S-transferase.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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