Linked Life Data

7374780

Source:http://linkedlifedata.com/resource/pubmed/id/7374780

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5762
pubmed:dateCreated
1980-7-26
pubmed:abstractText
The DNA synthetic (S) phase of cell division is about twice as long in human basal cell carcinoma (BCC) as the normal epidermis and several non-malignant skin diseases. A similar increase in S phase duration seems to occur in tumours of the human oesophagus, larynx and recto-colon. At the molecular level, the overall rate of replication in a nucleus is determined by two factors--the frequency of initiation of replication and the rate of replication fork progression along the units of replication (for review see refs 7,8). Here we present evidence (based on DNA fibre autoradiography) that the observed increase in S phase duration may be due to a marked reduction in the rate of DNA replication along replication units, the density of simultaneously operating replication units remaining unchanged. This indicates an alteration in some biological component(s) of DNA synthesis in BCC that is of potential interest for characterizing the malignant transformation of the epidermal cell and that may perhaps be exploited therapeutically.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Decreased rate of DNA-chain growth in human basal cell carcinoma.
pubmed:publicationType
Journal Article