Linked Life Data

7370151

Source:http://linkedlifedata.com/resource/pubmed/id/7370151

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-7-22
pubmed:abstractText
The effect on renal function of a large dose (25 micrograms kg-1) of fentanyl was investigated in 10 labrador dogs. The animals were anaesthetized with nitrous oxide in oxygen and a small supplement of fentanyl 0.4 microgram min-1 throughout the experiment, and muscular relaxation was provided by alcuronium, pulmonary ventilation being controlled. In the initial phase of each experiment, estimated renal plasma flow, glomerular filtration rate, urine volume, mean arterial pressure and renal vascular resistance were measured at 30-min intervals, three sets of samples being taken. Then the large dose of fentanyl was given over a 10-min period and the measurements were repeated at 30-min intervals for 90 min. Changes in renal function lasted for about 90 min; there was a significant decrease in estimated renal plasma flow (P less than 0.01), glomerular filtration rate (P less than 0.001), urine volume (P less than 0.01) and mean arterial pressure (P less than 0.001) together with an increase in renal vascular resistance (0.05 greater than P greater than 0.02). These changes were accompanied by bradycardia, but were still present when atropine was given.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0007-0912
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
343-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effect of anaesthesia with nitrous oxide in oxygen and fentanyl on renal function in the artificially ventilated dog.
pubmed:publicationType
Journal Article