Linked Life Data

7369219

Source:http://linkedlifedata.com/resource/pubmed/id/7369219

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-6-16
pubmed:abstractText
The relationship between cimetidine plasma levels and gastric acidity was studied in acutely ill patients. Patients in surgical intensive care for stress ulcer who were being managed with nasogastric suction were studied. Nine patients (Group 1) received 300 mg of intravenous cimetidine over 30 minutes every six hours. Titratable acidity and pH of gastric aspirates and plasma cimetidine levels were measured at peak (1.5--2.5 hours) and trough (5--6 hours) times following cimetidine administration, in Group 1. Titratable acidity and pH were measured for nine Group 2 patients (control) who did not receive cimetidine. In Group 1, mean gastric acid output was significantly lower (p less than 0.05) and mean pH was significantly higher (p less than 0.005) than in Group 2. In Group 1, plasma cimetidine concentration correlated poorly with gastric pH and gastric acid output (r = 0.21). The study indicates that the correlation between plasma cimetidine levels and gastric acid secretion is poor, but that the cimetidine dosage used suppressed acid output during the entire dosing interval.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9289
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Relationship between cimetidine plasma levels and gastric acidity in acutely ill patients.
pubmed:publicationType
Journal Article