Linked Life Data

7367757

Source:http://linkedlifedata.com/resource/pubmed/id/7367757

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-6-27
pubmed:abstractText
The effect of NiCl2 on digoxin induced cardiac arrhythmias were studied in anesthetized dogs and in isolated perfused hearts of rabbits, guinea pigs and rats. The results indicate that NiCl2 can effectively antagonize the digoxin induced cardiac arrhythmias in both intact as well as in isolated hearts. Sinus rhythm was restored and the cardiovascular status of the animal (which was digitoxic) eventually restored to normal. When not treated with NiCl2 the cardiovascular status of the dogs was progressively worsened leading to death. NiCl2 alone did not have any marked effect in normal hearts. It is likely that Ni2+ might be competing with Ca2+ at the cell membrane sites thereby antagonizing the toxic effects of digoxin. It is also possible that an increase in malic acid and oxaloacetic acid activity induced by NiCl2 may play a role in reversing the toxicity of digoxin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Reversal of digoxin induced cardiac arrhythmias by nickel chloride.
pubmed:publicationType
Journal Article, In Vitro