Linked Life Data

7365685

Source:http://linkedlifedata.com/resource/pubmed/id/7365685

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-6-27
pubmed:abstractText
Blood superfusion techniques were used to study the effects of verapamil on the body surface electrocardiogram and blood pressure of intact, anesthetized dogs as well as transmembrane action potential characteristics of isolated Purkinje fibers. Verapamil, 100 to 600 microgram/kg, administered in sequential doses intravenously to the intact (donor) animal caused a dose-dependent increase in the P-R interval and a decrease in systemic arterial pressure while exerting no significant effect on the normal, fast response Purkinje fiber action potential. To study effects of verapamil in depolarized fibers, maintained stretch was applied to Purkinje fibers until resting potentials had decreased from approximately -91 mV to a stable level of approximately -55 mV. For these fibers, verapamil, 400 microgram/kg, given as a single injection almost totally suppressed the slow response action potential while prolonging the P-R interval by less than 30% above control. These experiments suggest that in the presence of normal sinus and atrioventricular nodal function, plasma concentrations of verapamil which abolish the slow response action potential should have no major effect on sinus rate and atrioventricular conduction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
213
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effects of verapamil on electrophysiologic properties of blood superfused cardiac Purkinje fibers.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.