Linked Life Data

7364496

Source:http://linkedlifedata.com/resource/pubmed/id/7364496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1980-6-16
pubmed:abstractText
An antigen-binding radioimmunoassay was used to measure IgG, IgA and IgE antibody (ab) to Dermatophagoides pteronyssinus in sera from patients who had been hyposensitized with either aqueous D. pteronyssinus extract or placebo. An allergen, F4P1, was obtained from D. pteronyssinus culture and 125I-labelled for use in the assay. The radioallergosorbent test was also used to measure IgE ab to D. pteronyssinus and IgE ab to Dermatophagoides farinae. The radioimmunoassay results showed a selective rise in IgG ab in sera from D. pteronyssinus-treated (DP) patients. An increase of greater than twofold in IgG ab in post-treatment sera was found in 27 of 29 DP patients compared to 1 of 29 placebo-treated ('placebo') patients (p less than 0.001). The mean rise in IgG ab in DP patients was sixfold, and the maximum rise was 50-fold. There was little change in the levels of IgA ab or IgE ab in either DP or 'placebo' patients during treatment. The DP patients showed significant clinical improvement compared with the 'placebo' patients (p less than 0.01). However, no correlation was found between post-treatment IgG ab and post-treatment symptom scores, or between the changes in IgG ab and the changes in symptom scores during treatment. The time course of the antigen-binding assay was investigated using very low concentrations of F4P1. The results showed that antigen-binding was slow, even in the presence of an excess of IgG ab. The role of IgG ab in hyposensitization is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0020-5915
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-40
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Antibody response following prolonged hyposensitization with Dermatophagoides pteronyssinus extract.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial