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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1980-5-14
|
| pubmed:abstractText |
One hundred and one patients with rheumatoid arthritis were followed prospectively to assess the efficacy and toxicity of therapy with D-penicillamine. After a mean total followup of 11.5 months (38 patients have completed 2 years of followup) there was a 70% overall improvement rate with 2 complete remissions. Sixty-one patients developed 84 separate toxic reactions, 36 of which required drug withdrawal. Skin rashes (27/84), proteinuria (15/84), low platelets (14/84), and taste abnormalities (10/84) were the most common side effects of therapy at a mean D-penicillamine dose of 463 mg/day. The majority of toxic reactions (85%) occurred in the first 6 months, but proteinuria and thrombocytopenia were more common in the 6 to 12 month treatment period. Previous gold toxicity was a risk factor for developing D-penicillamine toxicity (10/13). Our observations suggest that D-penicillamine related toxicity is a major problem even at 500 mg/day, but the drug can be used with an increased safety margin after 9 months of continuous therapy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0004-3591
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
158-64
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7362666-Adolescent,
pubmed-meshheading:7362666-Adult,
pubmed-meshheading:7362666-Aged,
pubmed-meshheading:7362666-Arthritis, Rheumatoid,
pubmed-meshheading:7362666-Blood Sedimentation,
pubmed-meshheading:7362666-Child,
pubmed-meshheading:7362666-Digestive System,
pubmed-meshheading:7362666-Dose-Response Relationship, Drug,
pubmed-meshheading:7362666-Female,
pubmed-meshheading:7362666-Gold,
pubmed-meshheading:7362666-Humans,
pubmed-meshheading:7362666-Male,
pubmed-meshheading:7362666-Middle Aged,
pubmed-meshheading:7362666-Neutropenia,
pubmed-meshheading:7362666-Penicillamine,
pubmed-meshheading:7362666-Proteinuria,
pubmed-meshheading:7362666-Remission, Spontaneous,
pubmed-meshheading:7362666-Substance Withdrawal Syndrome,
pubmed-meshheading:7362666-Taste Disorders,
pubmed-meshheading:7362666-Thrombocytopenia,
pubmed-meshheading:7362666-Time Factors
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
The toxicity pattern of D-penicillamine therapy. A guide to its use in rheumatoid arthritis.
|
| pubmed:publicationType |
Journal Article
|