Linked Life Data

7362048

Source:http://linkedlifedata.com/resource/pubmed/id/7362048

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1980-5-23
pubmed:abstractText
Cardiac output and distribution of blood flow using 15-micron radioactively labelled microspheres were determined in 25 Wistar rats. In seven awake control animals, first and second injections of microspheres did not change cardiac output (137 +/- 8 ml/min) or result in alteration in apparent blood flow to the various organs studied. Halothane anesthesia (n = 6) (1.3 per cent inspired) resulted in a decrease in cardiac output, with increases in the percentages of cardiac output going to the brain, kidney, liver and large intestine. Enflurane anesthesia (n = 6) (2.2 per cent inspired) did not decrease cardiac output. The percentages of cardiac output going to the liver, lung, spleen, and large intestine increased. Both halothane and enflurane caused decreases in the percentages of cardiac output going to the heart and skeletal muscle. Ketamine anesthesia (n = 6) (125 mg/kg, im) differed from the other two agents in that few changes occurred from the awake state except in brain, lung and muscle, Microspheres that were trapped after the first injection were released from muscle and skin with ketamine anesthesia, resulting in an apparent decrease in the distribution of cardiac output to muscle in the controls and an apparent increase in "flow" to the lung. The microsphere method gives reliable information about cardiac output and distribution of flow in rats anesthetized with halothane or enflurane. Further studies are necessary to determine whether microsphere studies are valid indicators of organ flow during ketamine anesthesia in the rat.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0003-3022
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
296-302
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Whole-body distribution of radioactively labelled microspheres in the rat during anesthesia with halothane, enflurane, or ketamine.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.