Linked Life Data

7360524

Source:http://linkedlifedata.com/resource/pubmed/id/7360524

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-5-14
pubmed:abstractText
Na-dependent L-lysine epithelial transport was assessed in vitro by measuring the intracellular accumulation and unidirectional influx across the enterocyte brush border membrane. Pieces of jejunum were obtained by peroral biopsies from 27 "control" children and 2 cystinuric patients. In these patients, the following observations are recorded: 1) Na-dependent lysine intracellular accumulation is eliminated; 2) Na-independent accumulation persists (the accumulation ratio is 1.69 +/- 0.34); 3) Na-intracellular concentration is significantly higher in cystinuric patients (60.2 +/- 4.2 mEq/liter) than in controls (42.0 +/- 4.2 mEq/liter), and 4) lysine influx at the luminal membrane is measurable only in tracer amounts, both in the presence of Na (0.17 +/- 0.03 mumole/h cm2) and in it absence (0.22 +/- 0.09 mumole/h cm2). These results suggest a specific loss of Na-dependent L-lysine transport at the luminal membrane of the enterocyte in both the patients with cystinuria. The basolateral membrane is probably permeable to L-lysine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Cystinuria: reduced lysine permeability at the brush border of intestinal membrane cells.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro