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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1980-5-14
|
| pubmed:abstractText |
Four novel steroidal alpha-methylene delta-lactones have been synthesized and shown to be active against human nasopharyngeal carcinoma (KB) cells in culture. The syntheses involved the use of known alpha-methylenation procedures. In addition, the lactone 6 was directly methylenated by reaction with CH2O/KOH or Et2NH/CH2O/Et2NH.HCl. The formation of a cysteine adduct (15) with the alpha-methylene lactone 10 is reported.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
90-2
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7359520-Antineoplastic Agents,
pubmed-meshheading:7359520-Cell Division,
pubmed-meshheading:7359520-Cells, Cultured,
pubmed-meshheading:7359520-Humans,
pubmed-meshheading:7359520-Lactones,
pubmed-meshheading:7359520-Nasopharyngeal Neoplasms,
pubmed-meshheading:7359520-Structure-Activity Relationship
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
Steroidal alpha-methylene delta-lactones as potential antitumor agents.
|
| pubmed:publicationType |
Journal Article
|