Linked Life Data

7358977

Source:http://linkedlifedata.com/resource/pubmed/id/7358977

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-5-14
pubmed:abstractText
The genetic basis of the BALB/c anti-PC response pattern was studied in allotype and H-2 congenic mouse strains. In both a T-dependent (PC-KLH) and a T-independent (R36A) system, one of the major anti-PC idiotypes, the M511 IdI, is under specific clonal regulation. The expression of the two other major anti-PC idiotypes, T15 and M603X, is independent of such control. The expression of the M511 IdI is controlled by more than one gene, with at least one of the genes unlinked to either the Igh or the H-2 locus. Low responder mice, such as BALB/c, possesses the relevant genetic information coding for the H and L chains of the M511 Idi-positive antibodies, indicating that the expression of this idiotype is dependent on a specific regulatory mechanism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1068-74
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Specific clonal regulation in the response to phosphocholine. I. Genetic analysis of the response of a distinct idiotype (M511 Id).
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.