Linked Life Data

7358033

Source:http://linkedlifedata.com/resource/pubmed/id/7358033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1980-5-30
pubmed:abstractText
The capability of rabbit uterus and liver to hydrolyze estrone sulfate (E1S) to estrone (E1) was demonstrated in vitro by superfusion of tissue slices with mixtures of [3H]-E1S and [14C]E1. However, capillary barriers or binding factors may prevent the utilization of the blood-borne estrogen sulfate. To evaluate the extent of uptake of circulating E1S by uterine cells, a mixture of [3H]E1S and [14C]E1 was injected into the abdominal aorta of anesthetized rabbits. Shortly after the injection, samples of blood, uterine tissue, and liver were simultaneously taken. Isotope ratios in E1 isolated from these samples were measured and compared. The 3H to 14C ratios in E1 isolated from the uterus and from plasma were similar. It was concluded from these results that blood-borne E1S was not taken up directly by the uterus, since, otherwise, uterine E1 would be expected to have a higher 3H to 14C ratio than plasma E1. The isotope ratios in hepatic E1 were higher than those in E1 isolated from plasma or uterus, probably as a result of direct uptake of [3H]E1S by the liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1193-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
In vivo uptake of estrone sulfate by rabbit uterus.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S.