Linked Life Data

7351636

Source:http://linkedlifedata.com/resource/pubmed/id/7351636

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-3-27
pubmed:abstractText
The purpose of the study was to examine changes in the contractile responses to norepinephrine of aortas obtained from streptozotocin-induced diabetic rats and to determine the effects of changes in extracellular calcium (Ca++) concentrations on those contractile responses. Aortic rings from rats diabetic 14 to 20 days were supersensitive to norepinephrine in 0.20, 0.40 and 0.80 mM Ca++, but not in 2.50 mM Ca++. Aortas from rats diabetic 28 to 35 days showed a marked increase in contractile force to norepinephrine in 0.20, 0.40, 0.80 and 2.50 mM Ca++. The contractile force was significantly greater in the 28 to 35 day diabetic group as compared to the 14 to 20 day diabetic group. When the Ca++ concentration was changed from 2.50 mM to 0.20 and 0.40 mM, the aortas from the 28 to 35 days diabetic rats showed a significant decrease in developed tension. These data indicate that vascular reactivity is altered in experimental diabetes, and this alteration is related to the duration of the diabetic state and to the extracellular Ca++ concentration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
212
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Calcium dependence of norepinephrine-induced vascular contraction in experimental diabetes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.