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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1980-3-27
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pubmed:abstractText |
The suprachiasmatic nucleus (SCN) has been proposed as a site for an endogenous circadian oscillator in mammals, since lesions of the nucleus abolish a wide spectrum of overt-circadian rhythms. To demonstrate that a directly measurable property of the SCN itself in intact (unlesioned) animals is affected by environmental light and exhibits circadian rhythmicity, we used the autoradiographic 2-deoxy-D-[14C]glucose method to determine glucose utilization of rat SCN under a variety of lighting conditions. Our experiments indicate an important role for the SCN in circadian rhythm organization, and we believe the deoxyglucose method will prove useful as a tool for better understanding the functions and mechanisms of circadian clocks. Key words: suprachiasmatic nucleus, circadian rhythm, 2-deoxy-D-[14C]glucose.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9967
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
189
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-67
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7351445-Animals,
pubmed-meshheading:7351445-Autoradiography,
pubmed-meshheading:7351445-Circadian Rhythm,
pubmed-meshheading:7351445-Deoxyglucose,
pubmed-meshheading:7351445-Glucose,
pubmed-meshheading:7351445-Hypothalamus,
pubmed-meshheading:7351445-Hypothalamus, Anterior,
pubmed-meshheading:7351445-Light,
pubmed-meshheading:7351445-Male,
pubmed-meshheading:7351445-Rats
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pubmed:year |
1980
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pubmed:articleTitle |
In vivo metabolic activity of a putative circadian oscillator, the rat suprachiasmatic nucleus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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