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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4426
|
| pubmed:dateCreated |
1980-2-26
|
| pubmed:abstractText |
Cerebrovascular permeability of four modified opioid peptides--[D-Ala2]methionine enkephalin amide, beta-[D-Ala62,14C-Homoarg69]lipotropin 61 -69, alpha-[D-Ala2,14C-Homoarg9]endorphin, and beta-[D-Ala2,14C-Homoarg]endorphin--ranged from 1.4 to 3.9 X 10(-6) centimeters per second in brain regions of the conscous rat. These significant permeabilities should allow the peptides to fill the extracellular brain space with a half time of 3 to 11 minutes, as a result of a step increase in plasma concentration of unbound peptide.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0036-8075
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
4
|
| pubmed:volume |
207
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
84-6
|
| pubmed:dateRevised |
2007-3-19
|
| pubmed:meshHeading |
pubmed-meshheading:7350645-Animals,
pubmed-meshheading:7350645-Blood-Brain Barrier,
pubmed-meshheading:7350645-Brain,
pubmed-meshheading:7350645-Capillary Permeability,
pubmed-meshheading:7350645-Endorphins,
pubmed-meshheading:7350645-Enkephalins,
pubmed-meshheading:7350645-Extracellular Space,
pubmed-meshheading:7350645-Male,
pubmed-meshheading:7350645-Rats,
pubmed-meshheading:7350645-Solubility,
pubmed-meshheading:7350645-beta-Lipotropin
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
Entry of opioid peptides into the central nervous system.
|
| pubmed:publicationType |
Journal Article
|