Linked Life Data

7346733

Source:http://linkedlifedata.com/resource/pubmed/id/7346733

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-10-21
pubmed:abstractText
Replacement therapy for six weeks with human growth hormone (hGH) in deficient children has been shown to produce a significant lengthening of amobarbital t1/2. Studies to define the time course of this effect were carried out and indicate either no change or a minimal change after one to eight days of treatment. The increased t1/2 noted at six weeks persists for at least one year. In contrast to amobarbital, theophylline was found to exhibit a shortening of t1/2 from a mean of 7.52 +/- 4.44 (SD) to a mean of 3.38 +/- 1.23 hours in four subjects. Thus, replacement therapy with hGH results in quantitatively large but opposite changes in the elimination of these two drugs. For both substrates, however, t1/2 after hGH replacement more closely resembles values reported for normal subjects. This suggests that hGH may be a major determinant of in vivo drug elimination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0270-322X
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-70
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effect of growth hormone on human drug metabolism: time course and substrate specificity.
pubmed:publicationType
Journal Article