Linked Life Data

734417

Source:http://linkedlifedata.com/resource/pubmed/id/734417

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1979-3-24
pubmed:abstractText
The role of glutathione in the toxicity of styrene has been proposed based on the observations that glutathione inhibits the covalent binding of styrene and styrene oxide in vitro and that the administration of these compounds to animals decreases the glutathione content in the liver in vivo. In this study methionine (a precursor of reduced glutathione) or diethylmaleate (a depletor or reduced glutathione) was administered to hamsters concomitantly with styrene. Methionine protected the liver against the hepatotoxicity of styrene as indicated by the serum alanine aminotransferase activity. Diethylmaleate potentiated the hepatotoxic effect of styrene. A threshold value for hepatic glutathione of about 1 mmol/l was found for styrene toxicity. Cell damage occurred when the concentration of reduced glutathione in the liver has a central role in the development of cell damage caused by styrene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0355-3140
pubmed:author
pubmed:issnType
Print
pubmed:volume
4 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
The role of glutathione in the toxicity of styrene.
pubmed:publicationType
Journal Article