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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1979-3-24
|
| pubmed:abstractText |
Workers exposed to styrene in the reinforced plastics industry show a significant increase of chromosome aberrations, mainly chromosome breaks, in peripheral blood lymphocytes. The high incidence of aberrant lymphocytes (mean 15.1 +/- 4.8%; referents 2.0 +/- 1.3 %) was retained when the same men were reexamined one year later (mean 16.2 +/- 2.9 %). However, the frequency of sister chromatid exchanges (SCE), a newly developed sensitive parameter for the detection of recombinational exchanges linked with DNA repair, was not significantly increased (mean 5.3 +/- 1.0 SCE/cell) in comparison to the referents (mean 4.4 +/- 0.6 SCE/cell). This finding suggests a specific role of styrene or its metabolites in inducing genetic lesions mainly manifesting themselves as chromosomal breaks.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0355-3140
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4 Suppl 2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
259-64
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:734413-Adult,
pubmed-meshheading:734413-Chromatids,
pubmed-meshheading:734413-Chromosome Aberrations,
pubmed-meshheading:734413-DNA Repair,
pubmed-meshheading:734413-Environmental Exposure,
pubmed-meshheading:734413-Humans,
pubmed-meshheading:734413-Lymphocytes,
pubmed-meshheading:734413-Male,
pubmed-meshheading:734413-Mandelic Acids,
pubmed-meshheading:734413-Middle Aged,
pubmed-meshheading:734413-Occupational Medicine,
pubmed-meshheading:734413-Smoking,
pubmed-meshheading:734413-Styrenes,
pubmed-meshheading:734413-Time Factors
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Chromosome aberrations in lymphocytes of workers exposed to styrene.
|
| pubmed:publicationType |
Journal Article
|