Linked Life Data

7343557

Source:http://linkedlifedata.com/resource/pubmed/id/7343557

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-8-14
pubmed:abstractText
1 Electrical stimulation of mouse vasa deferentia or of rat occipital cortex slices which had been previously incubated with 3H-(-)noradrenaline increased the overflow of tritium from the tissue above that occurring spontaneously. 2 Phentolamine (10 micrometers) increased evoked tritium overflow from vasa deferentia as did both phentolamine and yohimbine (1.25 micrometers) when applied to cortex slices. 3 Evoked tritium overflow from cortex slices was increased by cocaine (20 micrometers) but neither cocaine (11 micrometers) nor desmethylimipramine (0.5 micrometers) increased evoked tritium overflow significantly in the vas deferens. 4 In contrast to its effect when applied alone, in the presence of phentolamine, cocaine produced a further increase in evoked tritium overflow in both tissues. 5 Application of (-)-noradrenaline in the presence of cocaine produced a reduction in evoked tritium overflow which was quantitatively similar in both tissues. 6 It is suggested that the effect on tritium overflow of blockade of the reuptake of noradrenaline by cocaine is masked in mouse vas deferens by a compensatory process mediated through presynaptic alpha-adrenoreceptors. 7 It may be that such a compensation does not occur in cortex slices because of a difference in the architecture of the synapse in this tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0144-1795
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
385-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Effect of noradrenaline reuptake blockade on evoked tritium overflow from mouse vasa deferentia and rat cortex slices previously incubated with 3H-noradrenaline.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't