Linked Life Data

7343284

Source:http://linkedlifedata.com/resource/pubmed/id/7343284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
39
pubmed:dateCreated
1982-8-26
pubmed:abstractText
In a randomised, double-blind study 5,000 IU heparin-dihydroergotamine mesylate (Dihydergot) or placebo were administered over 14 days to 107 patients with recent ischaemic cerebrovascular accident. The patients were studied daily for recent venous thrombosis in the legs by means of the 125I-fibrinogen test. Thirteen patients died before venous thrombosis had been demonstrated, 13 others were excluded by other causes. Of the 41 patients in the placebo group 23 developed venous thrombosis, but only 11 of the 40 drug-treated patients. Bilateral venous thrombosis occurred in six patients on the placebo and one patient on the drug. Univariate analysis indicated that heart failure, reduction of muscle tone, muscular power and level of consciousness favoured thrombosis. Multivariate analysis further indicated that both bed-rest of several days before start of the prophylactic treatment and extreme obesity favoured thrombosis. The relative thrombosis risk increased by a factor of 15.2 when prophylactic measures were omitted. Death rate in the treated group ws 17.4%, in the placebo group 28.0%. These results indicate that a prophylactic regimen of the type described is a practicable and effective measure after recent ischaemic cerebrovascular accident.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0012-0472
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1254-60
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[Prevention of venous thrombosis in recent ischaemic cerebrovascular accident: double-blind study with heparin-dihydroergotamine (author's transl)].
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Randomized Controlled Trial