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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1982-7-8
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pubmed:abstractText |
1 The metabolism of antipyrine to its three main oxidative metabolites, 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norphenazone was investigated in vivo and in vitro in separate groups of subjects with normal hepatic function and in the same group of patients with suspected liver disease. 2 The rank order for the rate of formation of the three metabolites of antipyrine was similar in vivo and in vitro. 3 There was no significant correlation between the rates of formation of any pair of antipyrine metabolites either in vivo or in vitro. 4 Despite this there was a significant correlation between the in vivo and in vitro rates for formation of each of the three metabolites in the same group of patients. 5 It is concluded that determination of rates of formation of antipyrine metabolites from their excretion in urine provides an indication of the activity of the enzymes involved in their formation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-111889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-119355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-399809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-4146319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-433309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-4356419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-4418208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-4593769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-4611464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-461498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-4813341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-487696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-522906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-533575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-5389794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-5690279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-6105054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-6766729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-732536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-7362740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-7448333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7340879-849678
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
771-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7340879-Adult,
pubmed-meshheading:7340879-Aged,
pubmed-meshheading:7340879-Antipyrine,
pubmed-meshheading:7340879-Female,
pubmed-meshheading:7340879-Half-Life,
pubmed-meshheading:7340879-Humans,
pubmed-meshheading:7340879-Hydroxylation,
pubmed-meshheading:7340879-Kinetics,
pubmed-meshheading:7340879-Liver,
pubmed-meshheading:7340879-Male,
pubmed-meshheading:7340879-Microsomes, Liver,
pubmed-meshheading:7340879-Middle Aged,
pubmed-meshheading:7340879-Oxidation-Reduction
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pubmed:year |
1981
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pubmed:articleTitle |
Comparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in man.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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