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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1982-6-21
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pubmed:abstractText |
1. A two-electrode voltage clamp method was used to study Ca inward currents in identified Helix aspersa neurones bathed in 25 mM-Ca, Na-free saline with TEA and 4-AP. 2. Inward currents were blocked by CdCl2. In Cd delayed outward currents appeared at +30 mV. When two identical depolarizations were separated by a gap inward current turned off to the same level during the two pulses up to +20 mV; above this potential the records cross over. 3. The turn-off of inward current at potentials up to +20 mV was not affected by 0.2 mM-quinine, which reduced outward currents at more depolarized potentials. Inward currents declined exponentially over the first 100 msec with a time constant around 60 msec at 0 mV. Double-pulse experiments gave the same time course of turn-off. 4. When Ca inward current was reduced by lowering [Ca]o or by partial block by Cd the rate and extent of turn-off was reduced. 5. The inactivation curve (obtained using a double pulse with gap method) was U-shaped. The curve was not significantly changed by addition of quinine (0.2 mM) or by changing test pulse size. 6. Recovery of inward currents after a depolarizing prepulse was a double-exponential process, with time constants of 120 msec and 9.4 sec at 10--11 degrees C. 7. Our results are discussed in terms of possible Ca-dependent Ca inactivation and in terms of the possibility of development of an outward Ca-dependent K current.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-103199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-1177091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-1177092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-1177093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-12991237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-14398823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-14448232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-286336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-31573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-352237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-409839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-439033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-4575321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-4584559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-458645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-4859233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-5500995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-5501056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-5527576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-591911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-6247486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-6250097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-6251744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-6257894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-6262506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-6267262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-652038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-660160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-7230017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-7230018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-7381770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-886608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-903906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7338811-994042
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
321
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-85
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1981
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pubmed:articleTitle |
Calcium current inactivation in identified neurones of Helix aspersa.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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