Linked Life Data

7336174

Source:http://linkedlifedata.com/resource/pubmed/id/7336174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-5-21
pubmed:abstractText
When normal human peripheral blood mononuclear cells were tissue-cultured in autologous serum under conditions permitting cell contact, spontaneous fluctuations in cytotoxic activity were found. An analysis demonstrated that monocytes have the capacity to suppress initially (days 1-2) natural killer (NK) activity and that, at later time points (days 3-7), cytotoxic activity against the NK-susceptible target cell Molt-4 occurs which increases above initial NK levels. The newly induced killing depended on adequate cell contact for its induction and correlated with spontaneous proliferation in the cultures. The monocyte-induced NK suppression was found to be independent of cell contact and inhibited by the presence of indomethacin, thus most probably mediated by secreted prostaglandins. Suppressed NK cells (at day 1) had a lower number of target-binding cells (TBCs) and a smaller fraction of active NK cells among TBCs as compared with control cells. The fluctuations in cytotoxicity as seen in the present in vitro system are discussed in relation to clinical conditions with decreased NK activity, such as multiple sclerosis and Hodgkin's disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
555-63
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Monocyte-induced human natural killer cell suppression followed by increased cytotoxic activity during short-term in vitro culture in autologous serum.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't