Linked Life Data

7335110

Source:http://linkedlifedata.com/resource/pubmed/id/7335110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-5-12
pubmed:abstractText
The phototoxicity and the photomutagenicity of the 2 linear furocoumarins 8-methoxypsoralen (8-MOP) and 8-isoamylenoxypsoralen (8-IOP) and of the angular derivative 5'-methylangelicin (5'-MA) were studied in 2 different test systems. In human lymphocytes, sister-chromatid exchange analysis (SCE analysis) was carried out. We found an increase in SCE frequency after treatment with 8-MOP and 5'-MA, but no enhancement was caused by 8-IOP. In the algal system Chlamydomonas reinhardii, 8-MOP and 5'-MA showed a similarly strong influence with regard to phototoxicity; 8-IOP exhibited a weaker effect within the same irradiation time. For photomutagenicity in Chlamydomonas, 8-MOP proved to be the strongest derivative; 8-IOP, however, was capable of inducing about the same numbers of revertants, but only under certain conditions. The angular 5'-MA showed a weak mutagenic activity in contrast to the psoralens. The influence of the structure of the derivatives and of the experimental conditions on the effects obtained are discussed with regard to the therapeutic risk of monofunctional and bifunctional furocoumarins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
451-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Mutagenicity and toxicity of furocoumarins: comparative investigations in 2 test systems.
pubmed:publicationType
Journal Article, Comparative Study