Linked Life Data

7332441

Source:http://linkedlifedata.com/resource/pubmed/id/7332441

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1982-4-12
pubmed:abstractText
Human colorectal tumors transplanted in immune-suppressed mice (xenogeneic system) and metastasizing Lewis lung carcinoma (syngeneic system) were used to study the effect of macrophages on tumor progression. Carrageenan modifying the structure of macrophage cell coat and damaging the membrane of lysosomes led to severe disturbances in macrophage functions. The inhibition of macrophage activity by Carrageenan produced an enhancement in tumor take in both systems. In another set of experiments peritoneal macrophages were injected into tumor-bearing mice. In both systems the non-stimulated macrophages given i.v., produced a delay in tumor growth. These results indicated that the activity of macrophages influences markedly the tumor progression--even in hosts with damaged T cell population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-911X
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
475-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Effect of macrophages on the growth of syn- and xenogeneic tumors.
pubmed:publicationType
Journal Article