Linked Life Data

7329441

Source:http://linkedlifedata.com/resource/pubmed/id/7329441

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1982-4-20
pubmed:abstractText
In vitro maintained second stage Toxocara canis larvae do not bind antiserum raised to their excretions and secretions (ES) at 37 degrees C as detected by indirect fluorescence. However, when these larvae were incubated at 2 degrees C under the same conditions intense fluorescence on the whole outer surface was observed. This fluorescence remained as long as the larvae were maintained at 2 degrees C. When these larvae were reincubated at 37 degrees C a gradual loss of fluorescence along their outer surfaces occurred. This loss was complete after 3 h. Larvae which were preincubated in antimetabolites at 37 degrees C exhibited intense fluorescence on their outer surfaces as did those incubated at 2 degrees C with antimetabolites. It is concluded that antigens present in ES occur along the whole length of the larval outer surface and turn over at 37 degrees C. This turnover occurs along the whole outer surface and is metabolically dependent. Should this occur in vivo it could afford the parasite with a mechanism for evasion of the immune response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0166-6851
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-93
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The effect of temperature and antimetabolites on antibody binding to the outer surface of second stage Toxocara canis larvae.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't