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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1976-10-1
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pubmed:abstractText |
Tests conducted on isolated and denervated preparations of the rat seminal duct brought evidence that tricyclic antidepressants (melipromine, noverile and azaphen) when employed in low concentrations (1-10(-9) g/ml) produced an adrenosensitizing effect. Denervation with the subsequent block by desoxycorticosterone (1-10(-5) g/ml) of exteraneuronal amine uptake did not alter the position, shape and inclination of the "concentration-effect" noradrenaline curves received in the presence of noverile and cocaine. It is believed that there exists a predominance of the postsynaptic mechanism of the aminosensitizing action of tricyclic antidepressants on the smooth muscle organ.
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pubmed:language |
rus
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0365-9615
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
556-8
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pubmed:dateRevised |
2008-10-8
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pubmed:meshHeading |
pubmed-meshheading:7328-Animals,
pubmed-meshheading:7328-Antidepressive Agents, Tricyclic,
pubmed-meshheading:7328-Cocaine,
pubmed-meshheading:7328-Dibenzazepines,
pubmed-meshheading:7328-Dose-Response Relationship, Drug,
pubmed-meshheading:7328-Imipramine,
pubmed-meshheading:7328-Male,
pubmed-meshheading:7328-Muscle, Smooth,
pubmed-meshheading:7328-Muscle Denervation,
pubmed-meshheading:7328-Norepinephrine,
pubmed-meshheading:7328-Oxazines,
pubmed-meshheading:7328-Rats,
pubmed-meshheading:7328-Testis
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pubmed:year |
1976
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pubmed:articleTitle |
[Effect of blocking the neuronal and extraneuronal uptake of bioamines on the adrenosensitizing action of tricyclic antidepressants].
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pubmed:publicationType |
Journal Article,
In Vitro,
English Abstract
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