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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1982-4-20
|
| pubmed:abstractText |
(S)-(+)- and (R)-(-)-5-Allyl-5-(1-methyl-2-pentynyl)-2-thiobarbituric acid (1, thiohexital) were prepared. The anesthetic activity (loss of righting reflex) and acute toxicity of the optically pure enantiomers of 1 were compared to the racemic isomer in mice. The S(+) isomer was found to be more potent as an anesthetic agent than the R(-) or RS(+/-) isomers. The therapeutic index was 2.5, 2.4, and 3.2 for the RS(+/-), R(-), and S(+) isomers, respectively. There were no significant differences in onset and duration of anesthesia when administered at the respective AD50 values. The prominent side effect is tremor, which is less for the S(+) isomer than for the R(-) or RS(+/-) isomers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1241-4
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7328585-Anesthetics,
pubmed-meshheading:7328585-Animals,
pubmed-meshheading:7328585-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7328585-Male,
pubmed-meshheading:7328585-Mice,
pubmed-meshheading:7328585-Mice, Inbred Strains,
pubmed-meshheading:7328585-Stereoisomerism,
pubmed-meshheading:7328585-Structure-Activity Relationship,
pubmed-meshheading:7328585-Thiamylal
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Synthesis and pharmacological activity of thiohexital enantiomers.
|
| pubmed:publicationType |
Journal Article
|