Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
1982-4-20
|
pubmed:abstractText |
A series of 1-substituted mitosene analogues of the mitomycin antitumor antibiotics was prepared by total synthesis and screened for activity against P388 leukemia in mice. In general, analogues with moderately good leaving groups (mostly esters) at the 1 position were active, whereas analogues without such substituents were inactive or barely active. These results lend support to the idea that mitosenes with leaving groups at position 1 are capable of bifunctional alkylation of DNA in a manner similar to that of mitomycin C. The most active mitosenes were equal in potency (minimum effective dose) to a corresponding aziridinomitosene, but they were less effective in prolonging life span.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
24
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1184-91
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:7328580-Animals,
pubmed-meshheading:7328580-Antineoplastic Agents,
pubmed-meshheading:7328580-Leukemia L1210,
pubmed-meshheading:7328580-Leukemia P388,
pubmed-meshheading:7328580-Mice,
pubmed-meshheading:7328580-Mitomycins,
pubmed-meshheading:7328580-Structure-Activity Relationship
|
pubmed:year |
1981
|
pubmed:articleTitle |
Synthesis and antineoplastic activity of mitosene analogues of the mitomycins.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|